In which condition is urine metanephrines increased?

In which condition is urine metanephrines increased?

Urine metanephrines can be elevated in pheochromocytoma. They are metabolites of catecholamines. Pheochromocytoma is tumor arising from the adrenal medulla. Sometimes the location can be extra adrenal. Catecholamines are produced in large amounts by this tumour and the metabolites are excreted in urine. But the tumour has to be confirmed by ultrasound / CT / MIBG scan. MIBG scan is specially useful in locating extra adrenal pheochromocytoma.