Lipoprotein (a) genetic variants

Lipoprotein (a) genetic variants

Lipoprotein (a) genetic variants: A study by Robert Clarke, John F Peden, Jemma C Hopewell, Theodosios Kyriakou, Anuj Goel, Simon C Heath, Sarah Parish, Simona Barlera, Maria Grazia Franzosi, Stephan Rust, Derrick Bennett, Angela Silveira, Anders Malarstig, Fiona R Green, Mark Lathrop, Bruna Gigante, Karin Leander, Ulf de Faire, Udo Seedorf, Anders Hamsten, Rory Collins, Hugh Watkins and Martin Farrall for the PROCARDIS Consortium published in the New England Journal of Medicine [1] used a novel gene chip containing 48742 single nucleotide polymorphisms (SNPs) in 2100 genes to test for associations in about 6500 persons {controls and those with coronary artery disease (CAD)}. It was found that three chromosomal regions (6q26–27, 9p21, and 1p13) were strongly associated with the risk of CAD. They identified a common variant at the LPA locus with an odds ratio of CAD of 1.7 and another independant variant with an odds ratio of 1.92. These variants were strongly associated with increased level of Lp(a) lipoprotein.

Reference

1. Robert Clarke, John F Peden, Jemma C Hopewell, Theodosios Kyriakou, Anuj Goel, Simon C Heath, Sarah Parish, Simona Barlera, Maria Grazia Franzosi, Stephan Rust, Derrick Bennett, Angela Silveira, Anders Malarstig, Fiona R Green, Mark Lathrop, Bruna Gigante, Karin Leander, Ulf de Faire, Udo Seedorf, Anders Hamsten, Rory Collins, Hugh Watkins, Martin Farrall, PROCARDIS Consortium. Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med. 2009 Dec 24;361(26):2518-28.