The eight previously known Brugada syndrome (BrS) susceptibility genes are [three sodium channel (SCN) genes, two potassium channel(KCN) genes, two calcium channel (CACN) genes and one glycerol-3-phosphate dehydrogenase(GPD) 1-like gene]:
BrS9: KCND3 – recently described as given below (official designation awaited):
Giudicessi JR and associates [Transient outward current (Ito) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome. Heart Rhythm. 2011; 8:1024-1032] have identified what is possibly the ninth gene for Brugada syndrome mutation in the KCND3-encoded Kv4.3 (Ito), which is a missense mutation. These mutations (Kv4.3-L450F and Kv4.3-G600R) had a gain-of-function phenotype which increased the peak Ito (transient outward) current density. This (KCND3 mutation) should qualify for ninth genotype of Brugada syndrome to be identified. The authors also demonstrated a stable loss of the action potential dome due to the increased Ito maximal conductance with these mutations.