P2Y12 reaction units for on-treatment platelet reactivity (OTR)

P2Y12 reaction units for on-treatment platelet reactivity (OTR)

Platelet reactivity can be measured in P2Y12 reaction units (PRU) and can be used to assess on-treatment platelet reactivity (OTR) after percutaneous coronary interventions (PCI). Platelet reactivity of 230 or more P2Y12 reaction units while on clopidogrel has been taken as high platelet reactivity with a VerifyNow P2Y12 Assay [1].

Reference

1. Matthew J Price, Dominick J Angiolillo, Paul S Teirstein, Elizabeth Lillie, Steven V Manoukian, Peter B Berger, Jean-François Tanguay, Christopher P Cannon, Eric J Topol. Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial. Circulation. 2011 Sep 6;124(10):1132-7.