1 mmol/l (38.7 mg/dl) reduction in LDL cholesterol can lower atherosclerotic cardiovascular events by — in a few years – Correct answer: a) 20%
This has been derived from over 25 cardiovascular outcome trials with statins . Cholesterol Treatment Trialists’ (CTT) Collaboration conducts periodic meta analysis of trials with 1000 or more participants and follow up of 2 years or more. They used individual participant data and the trials were mostly on statins. Data on 170,000 participants in 26 randomised trials was published in the Lancet . Across 26 trials, 10% reduction in all cause mortality was noted per 1 mmol/l reduction in LDL cholesterol (p<0·0001).
Major cardiovascular events were reduced by a fifth for 1 mmol/l lowering of LDL cholesterol. It was further suggested that 2-3 mmol/l reduction in LDL could bring about a reduction of events by 40-50%.