Reynolds risk score for prediction of coronary artery disease

Reynolds risk score for prediction of coronary artery disease

Reynolds risk score was derived in a cohort of about 25,000 healthy women from the United States [1]. It includes traditional risk factors used in the Framingham risk score along with parental family history of premature coronary artery disease and high-sensitivity C-reactive protein. They assessed 35 risk factors among 24,558 initially healthy US women 45 years or older who were followed up for a median of 10.2 years.

Incident cardiovascular events were adjudicated as composite of myocardial infarction, ischemic stroke, coronary revascularization, and cardiovascular death. Randomly selected two third (16,400) datasets were used as a derivation cohort to develop new risk algorithm and the remaining one third (8158) were used as the validation cohort to compare observed and predicted outcomes.

Though originally derived in a female cohort, Reynolds risk score has also been calibrated for males [2] and both these have been superior to Framingham risk score in a few studies. For the development of the score, 10,724 initially healthy American nondiabetic men were followed up for a median period of 10.8 years.

The naming is after the main center where it was developed: Donald W. Reynolds Center for Cardiovascular Research.

References

1. Paul M Ridker, Julie E Buring, Nader Rifai, Nancy R Cook. Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women: The Reynolds Risk Score. JAMA. 2007 Feb 14;297(6):611-9.
2. Paul M Ridker, Nina P Paynter, Nader Rifai, J Michael Gaziano, Nancy R Cook. C-reactive Protein and Parental History Improve Global Cardiovascular Risk Prediction: The Reynolds Risk Score for Men. Circulation. 2008 Nov 25;118(22):2243-51, 4p following 2251.