Betablockers in heart failure

Betablockers in heart failure

More benefit has been shown in heart failure with non selective beta blockers than with selective beta one blockers. Additional intrinsic sympathomimetic activity was found to be deleterious.
In CARMEN study, combination of carvedilol with enalapril was superior to either enalapril or carvedilol alone. In certain genotypes, bucindolol works better than carvedilol.