Bromocriptine has been shown to be useful in all except:
Correct answer: 3. Peripheral arterial disease
Bromocriptine is used for suppression of lactation and in the treatment of Parkinsonism. It has been shown to be useful in type 2 diabetes mellitus as well. Recent studies have shown its benefit in peripartum cardiomyopathy . Being an ergot derivative, one of the adverse effect noted in the study was peripheral arterial occlusion. 16kDa prolactin subunit has been shown to produce endothelial dysfunction cardiac muscle cell dysfunction in experimental studies. Prolactin can promote inflammation in peripartum cardiomyopathy. Inhibition of prolactin release with bromocriptine (dopamine D2 receptor agonist) may prevent onset of peripartum cardiomyopathy.
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- Hilfiker-Kleiner D, Haghikia A, Berliner D, Vogel-Claussen J, Schwab J, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfeld R, Stangl V, Kindermann I, Kühl U, Angermann CE, Schlitt A, Fischer D, Podewski E, Böhm M, Sliwa K, Bauersachs J. Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J. 2017 Sep 14;38(35):2671-2679.