Cor pulmonale is heart disease secondary to lung disease which causes pulmonary hypertension. It is associated with RVH, leading to right heart failure.
Sitaxentan, ambrisentan and atrasentan are selective endothelin A receptor antagonists. Bosentan and Tezosentan are non selective endothelin inhibitors.
Cardiovascular risks of obesity: Premature atherosclerosis, risk of myocardial infarction, heart failure, decreased survival, due to cardiovascular deaths.