Category: General Cardiology

RE-LY trial: In patients with AF, dabigatran given at a dose of 110 mg was associated with stroke rates similar to warfarin, but with less major bleeding.

Tripling the dose was found to be useful in those with heterozygous mutation producing clopidogrel resistance, while it was not useful in homozygous cases.

Ticagrelor is an antiplatelet agent belonging to a new class known as cyclopentyl triazolo-pyrimidines (CPTP) acting as a reversible allosteric antagonist.

Cardiac lesions in Behcet disease can be involve all three layers - pericarditis, myocarditis and endocarditis, with poor prognosis.

High altitude pulmonary edema is characterized by pulmonary vasoconstriction in response to reduced oxygen concentration in inhaled air at high altitude.

Pleiotropic effects of natriuretic peptides are natriuresis, suppression of RAAS, cytoprotective property, antihypertrophic action, anti fibrotic etc.

Dabigatran etexilate is indicated for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

A special formulation of doxorubicin reduce its toxicity is known as pegylated liposomal doxorubicin.

Cor pulmonale is heart disease secondary to lung disease which causes pulmonary hypertension. It is associated with RVH, leading to right heart failure.

Sitaxentan, ambrisentan and atrasentan are selective endothelin A receptor antagonists. Bosentan and Tezosentan are non selective endothelin inhibitors.