Medina classification assigns a binary value (1,0) to the three components of a coronary bifurcation depending on whether have > (1) or < (0) 50% lesion.
Coronary bifurcations with an angle of less than 70 degrees are known as Y-shaped bifurcation and those with more than 70 degrees T-shaped bifurcation.
The presence of hypertension in AS makes it (left ventricle) a double loaded LV with valvular obstruction and vascular resistance presenting dual loads.
RE-LY trial: In patients with AF, dabigatran given at a dose of 110 mg was associated with stroke rates similar to warfarin, but with less major bleeding.
Tripling the dose was found to be useful in those with heterozygous mutation producing clopidogrel resistance, while it was not useful in homozygous cases.