MACE vs NACE in coronary interventions

MACE vs NACE in coronary interventions

MACE = major adverse cardiovascular event(s)
Components of MACE are death, reinfarction, ischemia-driven target vessel revascularization, and stroke.
NACE = net adverse clinical event(s); NACE = (MACE + major bleeding unrelated to coronary artery bypass grafting)
The term NACE was introduced in the HORIZONS Trial [1].

Reference

1. Gregg W Stone, Bernhard Witzenbichler, Giulio Guagliumi, Jan Z Peruga, Bruce R Brodie, Dariusz Dudek, Ran Kornowski, Franz Hartmann, Bernard J Gersh, Stuart J Pocock, George Dangas, S Chiu Wong, Ajay J Kirtane, Helen Parise, Roxana Mehran, HORIZONS-AMI Trial Investigators. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218–2230.