Reversible and irreversible platelet inhibition by anti platelet agents

Reversible and irreversible platelet inhibition by anti platelet agents

Agents which irreversibly inhibit platelets are:

  1. Aspirin
  2. Ticlopidine
  3. Clopidogrel
  4. Prasugrel

In general all these agents except prasugrel are ideally discontinued 5 days prior to intended surgery. Prasugrel is better discontinued 7 days prior, because of slightly different pharmacodynamics profile.

Agents which reversibly inhibit platelets are:

  1. Dipyridamole
  2. Cilostazol
  3. Nonsteroidal anti-inflammatory drugs
  4. Ticagrelor