Risk of intracranial bleed for tenecteplase – Cardiology MCQ

Risk of intracranial bleed for tenecteplase in acute pulmonary embolism:
a) 2%
b) 5%
c) 10%
d) 15%
Correct answer: a) 2%
The incidence hemorrhagic stroke after thrombolysis of acute pulmonary embolism with tenecteplase was 2% while it was only 0.2% in those given heparin alone. But there was a significant reduction in all cause mortality / hemodynamic collapse in the tenecteplase treated group. Hence tenecteplase can be considered in all with hypotension and as rescue treatment in those with evidence of right ventricular dysfunction and myocardial injury.