InterTAK diagnostic score for Takotsubo cardiomyopathy

InterTAK diagnostic score for Takotsubo cardiomyopathy

InterTAK Diagnostic Score was developed from the results for International Takotsubo Registry [1] by the InterTAK International Registry Group. The score was developed for differentiating Takotsubo cardiomyopathy from acute coronary syndrome in the acute stage. InterTAK Diagnostic Score estimates the probability for Takotsubo cardiomyopathy and was found to have high sensitivity and specificity for differentiating it from acute coronary syndrome.

Points were allocated as follows:

Female gender: 25 points
Emotional trigger: 24 points
Physical trigger: 13 points
Absence of ST-segment depression: 12 points
Psychiatric disorders: 11 points
Neurologic disorders: 9 points
QTc prolongation: 6 points

If 50 or more points were present, the specificity of Takotsubo cardiomyopathy was 95%. If score was 31 or less, the specificity of acute coronary syndrome was also 95%.


  1. Ghadri JR, Cammann VL, Jurisic S, Seifert B, Napp LC, Diekmann J, Bataiosu DR, D’Ascenzo F, Ding KJ, Sarcon A, Kazemian E, Birri T, Ruschitzka F, Lüscher TF, Templin C; InterTAK co-investigators. A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry. Eur J Heart Fail. 2017 Aug;19(8):1036-1042.