Soluble ST2: ST2 (suppression of tumorigenicity 2) region on chromosome 11 is a locus associated with various forms of cancer. IL1R1 on chromosome 2 has the alias ST2 and encodes a member of the interleukin 1 receptor family . These two are often confused with each other in published literature.
Soluble form of ST2 (sST2) is a novel biomarker for cardiac risk prediction, which is secreted into the circulation. It has been used in the management of heart failure as a therapy guide. The other variant is transmembrane ST2 isoform known as ST2L .
ST2 is an interleukin-1 receptor family biomarker. Interleukin-1 like cytokine is secreted in response to cell damage. Circulating sST2 concentrations reflect myocardial stress and myocardial fibrosis .
sST2 values have been positively correlated with the severity of acute heart failure, B-type natriuretic peptide and C-reactive protein, and negatively correlated with ejection fraction and creatinine clearance . sST2 when used in combination with NT-proBNP (N-terminal pro-B–type natriuretic peptide) is useful in assessing prognosis in chronic heart failure beyond clinical risk scores .