Predominant mechanism of action of nitrates is venodilatation and decreased venous return, lowering myocardial preload and hence myocardial oxygen demand.
2010 AHA CPR guidelines (AHA CPR guidelines will be revised every 5 years. Please check the current guidelines at AHA website) 2010 AHA CPR guidelines: American Heart Association
Some studies have suggested that high levels of BNP in CKD indicate both reduced clearance of BNP by the kidneys as well as a compromised cardiac function.